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招待講演　Annick Pierce 教授の経歴

Laboratory address

Unity of Structural and Functional Glycobiology (UGSF), UMR 8576 du CNRS, University of Sciences and Technologies of Lille, 59655 Villeneuve d’Ascq, France

Phone number:  +33 (0) 3 20 43 72 38
FAX: +33 (0) 3 20 43 65 55　
e-mail: annick.pierce@univ-lille1.fr

University Degrees

MSc. in Biochemistry, University of Lille
PhD. University of Lille

Research Career

1977-1979: Ph.D. studentship at University of Lille, Department of Biochemistry, supervised by Pr. G Spik. Thesis title, « Comparison of the O-glycan moieties of the secretory immunoglobulin A (sIgA) compared to serum IgA”
1979-1983: State Thesis supervised by Pr. G Spik entitled « Structural studies of the N-glycans and the O-glycans of secretory immunoglobulin A (sIgA)”.
1983-2000 : CNRS Researcher : « Chargée de Recherche » (1st class from Octobre 1988)
2000- : Professor of Biochemistry, University of Science and Technology of Lille.

Actual Positions and Employment

  • Professor of Biochemistry
  • Team leader: “Regulation of cell cycle progression and apoptosis by delta-lactoferrin”
  • Unité de Glycobiologie Structurale et Fonctionnelle, UMR 8576 CNRS, 59655 Villeneuve d’Ascq Cedex

Member of the administration team of the UMR8576 CNRS

  • Member of the CSE (jury responsible for the selection and recruitment of Professors and lecturers for the Biology and Biochemistry departments)
  • Chairwoman of the VIIIth International Conference on Lactoferrin, Structure and Function, Nice, 21-25 October 2007 (http://www.lactoferrin-conference.com)
  • Co-editor with Dominique Legrand of the « Lactoferrin Special Issue » published by the journal Biochimie January 2009
  • Member of the scientific committee of the IXth International Conference on Lactoferrin, Beijing, 18-22 October 2009

Collaborations

  • Service d’Etude et de Recherche sur les Lipoprotéines et l’Athérosclérose, INSERM U325, Institut Pasteur de Lille et Université d’Artois, Lens (Dr. R. Cecchelli).
  • Parkinson’s Unit, The Charing Cross and Westminster Medical School, London, UK (Dr. D. Dexter).
  • Laboratoire de Neuropathologie, Hôpital R. Salengro, CHRU de Lille (Dr. M.-M. Ruchoux).
  • Laboratoire de Neuroendocrinologie et Physiopathologie Neuronale, INSERM U422, CHRU de Lille (Dr. J.-C. Beauvillain).
  • Laboratoire d’Oncologie moléculaire humaine, Centre Oscar Lambret, CHRU de Lille (Dr. J.-P. Peyrat).
  • UMR8576, O-GlcNAC group (Prof T. Lefebvre).
  • Department of Molecular Toxicology, Nagoya University (Pr. H. Tsuda and Dr D. Alexander).

Research Support

- Integrated franco-spanish action n° 244 « Study of the hormonal regulation of lactogenesis in the rat »

- Contract with the Nord-Pas-de-Calais Region « Neurodegenerative diseases and aging »

- Contract Genopole - Maladies multifactorielles et innovations thérapeutiques « Role of the antioxidant properties of brain lactoferrin in Parkinson’s disease »

- Contract ARC “Control of the division and differentiation of cancer cells by delta-lactoferrin”　　

- Ministère de l'Education Nationale de la Recherche et de la Technologie.

- Arcir Project: “Signaling and post-translational modifications during the development et dissemination of mammary gland and prostate cancers”

- ARC and Ligue contre le cancer « Study of the role of gangliosides, delta-lactoferrin and neutrophins in the development and progression of breast cancer » 

- PEPS : « Impact of the modification of beta-catenin and delta-lactoferrin by O-GlcNAc on their stability and transcriptional activity »

- Industrial contract « Antitumoral activity of lactoferrin isoforms: a comparative and quantitative approach.” Scientific coordinator A. Pierce, industrial coordinator Jean-Paul Perraudin (SC Ropharma SA, Roumania ; Grain-Root Corporation, Taïwan ; Groupe Soparind Bongrain, France ; Vitamed, China)

Selected peer-reviewed publications　

Lactoferrin field .

  1. A. Pierce, D. Colavizza, M. Benaïssa, P. Maes, A. Tartar, J. Montreuil & G. Spik. Molecular cloning and sequence analysis of bovine lactotransferrin. Eur. J. Biochem., 196 (1991), 177-184.　
  2. G. Spik, D. Legrand, B. Leveugle, J. Mazurier, T. Mikogami, J. Montreuil, A. Pierce & E. Rochard-Elass. Characterization of two kinds of lactoferrin receptors on different target cell, Adv. Exp. Med. Biol., 357 (1994), 13-20.　 N. Nillesse, A. Pierce, M. Benaïssa & G. Spik. Characterisation of the membrane receptor of human lactotransferrin on the megacaryocyte Dami cell line. Biol. Cell, 82 (1995), 149-159.　　
  3. H. Escriva, A. Pierce, B. Coddeville, F. Gonzales, M. Benaïssa, D. Léger, J.M. Wieruszeski, G. Spik & M. Pamblanco. Rat mammary gland transferrin : nucleotide sequence, phylogenic analysis and glycan structures. Biochem. J., 307 (1995), 47-55.　　　
  4. B. Faucheux, N. Nillesse, P. Damier, G. Spik, A. Mouatt-Pringent, A. Pierce, B. Leveugle, N. Kubis, J. Hauw, Y. Agid & E. Hirsch. Expression of lactoferrin receptors is increased in the mesencephalon of patients with Parkinson’s disease Proc. Natl. Acad. Sci. USA, 92 (1995), 9603-9607.　
  5. B. Dehouck, L. Fenart, M. P. Dehouck, A. Pierce, G. Torpier,　 & R. Cecchelli. A new function for the LDL receptor : transcytosis of LDL across the blood-brain barrier. J. Cell. Biol., 138　 (1997), 877-889
  6. C. Fillebeen, D. Dexter, V. Mitchell, M. Benaïssa, J. C. Beauvillain, G. Spik & A. Pierce. Lactoferrin is synthesized by mouse brain tissue and its expression is enhanced after MPTP treatment. Adv. Exp. Med. Biol., 443 (1998), 293-300.　
  7. C. Fillebeen, L. Descamps, M. P. Dehouck, L. Fenart, M. Benaissa, G. Spik, R. Cecchelli & A. Pierce. Receptor mediated-transcytosis of lactoferrin through the blood-brain barrier. J. Biol. Chem., 274  (1999), 7011-7017.
  8. C. Fillebeen, D. Dexter, V. Mitchell, M. Benaïssa, J. C. Beauvillain, G. Spik & A. Pierce. Lactoferrin is synthesized by mouse brain tissue and its expression is enhanced after MPTP treatment. Mol. Brain Res., 72 (1999), 183-194.　
  9. C. Fillebeen, M. P. Dehouck, I. Dhennin-Duthille, M. Benaïssa, R. Cecchelli & A. Pierce. TNF-a increases lactoferrin transcytosis through the blood-brain barrier. J. Neurochem., 73 (1999), 2491-2500.　
  10. C. Fillebeen, R. Cecchelli, D. Dexter, M. Benaïssa & A. Pierce. Brain lactoferrin : origins and mechanisms of accumulation in neurodegenerative disorders. Adv. Exp. Med. Biol. 67-76 (2000)　　
  11. Fillebeen C, Ruchoux MM, Mitchell V, Vincent S, Benaïssa M, Pierce A. Lactoferrin is synthesized by activated microglia in the human substantia nigra and its synthesis by the human microglial CHME cell line is upregulated by tumor necrosis factor a or 1-methyl-4-phenylpyridinium treatment.　 Mol. Brain Res. 2001, 96, 103-113　
  12. M. Breton, C. Mariller, M. Benaïssa, K. Caillaux, E. Browaeys, J.-P. Vilain, J. Mazurier and A. Pierce. Expression of delta-lactoferrin induces cell cycle arrest. Biometals 2004, 17, 325-329　
  13. D. Legrand, E. Elass, A. Pierce and J. Mazurier. Lactoferrin and host defense : an overview of its immuno-modulating and anti-inflammatory properties. Biometals 2004, 17, 225-229　
  14. M. Benaïssa, J.-P. Peyrat, L. Hornez, C. Mariller, J. Mazurier and A. Pierce Expression & prognostic value of lactoferrin mRNA isoforms in human breast cancer. Int. J. Cancer 2005, 114, 299-306　　
  15. C. Mariller, M. Benaïssa, M. Breton, S. Hardiville, G. Pradelle, J. Mazurier and A. Pierce. Human delta-lactoferrin is a transcription factor which enhances Skp1 (S-phase kinase associated protein) gene expression. FEBS J. 2007, 274, 2038-2053　
  16. C. Mariller, E. Hoedt, S. Hardiville, M. Benaïssa, J. Mazurier and A. Pierce. Proteomic approach to identification of novel delta-lactoferrin target genes: characterization of DcpS, an mRNA scavenger decapping enzyme, accepté dans Biochimie, 2008　
  17. D. Legrand, A. Pierce, E. Elass, M. Carpentier, C. Mariller, J. Mazurier, Lactoferrin structure and functions, Adv. Exp. Med. Biol., 2008, 606, 163-194

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